비스포스포네이트가 코팅된 티타늄 표면의 세포독성 평가
Cytotoxicity Evaluation of Titanium Surface Coated Bisphosphonate
강민경, 문승균, 김광만, 김경남,
소속 상세정보
강민경 ( Kang MIn-Kyung ) - 연세대학교 치과대학 치과생체재료공학교실
문승균 ( Moon Seung-Kyun ) - 연세대학교 치과대학 치과생체재료공학교실
김광만 ( Kim Kwang-Man ) - 연세대학교 치과대학 치과생체재료공학교실
김경남 ( Kim Kyoung-Nam ) - 연세대학교 치과대학 치과생체재료공학교실
KMID : 0362220110380010025
Abstract
The aim of this study was to evaluate cytotoxicity of bisphosphonate coated titanium. To coat the bisphosphonate on the titanium, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray Photoelectron spectroscopy. Cytotoxicity was evaluated by MTT assay. After the second coating step, we found that the modified titaniums were formed thick and homogeneous apatite layer that contained the bisphosphonate. Modified titanium were increased the loading of calcium and phosphate ion onto the surface. However, bisphosphonate coated titanium had more cytotoxicity as the concentration of bisphosphonate on the surface was increased. Therefore, these results suggested that further study should be done to demonstrate the effect and safety of this material at the different drug concentration.
키워드
Anodic oxidation; Biomimetic coating; Bisphosphonate; Cytotoxicity; Heat-treatment
원문 및 링크아웃 정보
등재저널 정보